Digit ratio (2D:4D) and maternal testosterone-to-estradiol ratio measured in early pregnancy
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Brown, W. M., Hines, M., Fane, B. A. & Breedlove, S. M. Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia. Horm. Behav. 42, 380–386 (2002).
Manning, J. T., Scutt, D., Wilson, J. & Lewis-Jones, D. I. The ratio of 2nd to 4th digit length: A predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Hum. Reprod. 13, 3000–3004 (1998).
Lutchmaya, S., Baron-Cohen, S., Raggatt, P., Knickmeyer, R. C. & Manning, J. T. 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Human Dev. 77, 23–28 (2004).
Manning, J. T. Resolving the role of prenatal sex steroids in the development of digit ratio. Proc. Natl. Acad. Sci. 108, 16143–16144 (2011).
Zheng, Z. & Cohn, M. J. Developmental basis of sexually dimorphic digit ratios. Proc. Natl. Acad. Sci. USA 108, 16289–16294 (2011).
Manning, J. T. Digit Ratio: A Pointer to Fertility, Behavior, and Health (Rutgers University Press, 2002).
Manning, J. T., Kilduff, L., Cook, C., Crewther, B. & Fink, B. Digit ratio (2D:4D): A biomarker for prenatal sex steroids and adult sex steroids in challenge situations. Front. Endocrinol. 5, 9 (2014).
Manning, J. T., Fink, B., Mason, L., Kasielska-Trojan, A. & Trivers, R. The effects of sex, nation, ethnicity, age and self-reported pubertal development on participant-measured right-left 2D:4D (Dr-l) in the BBC internet study. J. Biosoc. Sci. https://doi.org/10.1017/S0021932022000049 (2022).
Hönekopp, J. & Watson, S. Meta-analysis of digit ratio 2D:4D shows greater sex difference in the right hand. Am. J. Hum. Biol. 22, 619–630 (2010).
Richards, G. et al. Digit ratio (2D:4D) and congenital adrenal hyperplasia (CAH): Systematic literature review and meta-analysis. Horm. Behav. 126, 104867 (2020).
Richards, G. What is the evidence for a link between digit ratio (2D:4D) and direct measures of prenatal sex hormones?. Early Human Dev. 113, 71–72 (2017).
Fusar-Poli, L. et al. Second-to-fourth digit ratio (2D:4D) in psychiatric disorders: A systematic review of case-control studies. Clin. Psychopharmacol. Neurosci. 19, 26–45 (2021).
Manning, J. T., Reimers, S., Baron-Cohen, S., Wheelwright, S. & Fink, B. Sexually dimorphic traits (digit ratio, body height, systemizing-empathizing scores) and gender segregation between occupations: Evidence from the BBC internet study. Personality Individ. Differ. 49, 511–515 (2010).
Neyse, L., Johannesson, M. & Dreber, A. 2D:4D does not predict economic preferences: Evidence from a large, representative sample. J. Econ. Behav. Organ. 185, 390–401 (2021).
de Fonseca, C. A. D. et al. Digital biomarker 2D:4D as a predictor of cancer: A systematic review. Early Human Dev. 164, 105521 (2022).
Pratt, T. C., Turanovic, J. J. & Cullen, F. T. Revisiting the criminological consequences of exposure to fetal testosterone: A meta-analysis of the 2D:4D digit ratio. Criminology 54, 587–620 (2016).
Hönekopp, J. & Schuster, M. A meta-analysis on 2D:4D and athletic prowess: Substantial relationships but neither hand out-predicts the other. Personality Individ. Differ. 48, 4–10 (2010).
Pasanen, B. E. et al. The relationship between digit ratio (2D:4D) and muscular fitness: A systematic review and meta-analysis. Am. J. Hum. Biol. 34, e23657 (2022).
Berenbaum, S. A., Bryk, K. K., Nowak, N., Quigley, C. A. & Moffat, S. Fingers as a marker of prenatal androgen exposure. Endocrinology 150, 5119–5124 (2009).
van Hemmen, J., Cohen-Kettenis, P. T., Steensma, T. D., Veltman, D. J. & Bakker, J. Do sex differences in CEOAEs and 2D:4D ratios reflect androgen exposure? A study in women with complete androgen insensitivity syndrome. Biol. Sex Differ. 8, 11 (2017).
Wallen, K. Does finger fat produce sex differences in second to fourth digit ratios?. Endocrinology 150, 4819–4822 (2009).
Zitzmann, M. & Nieschlag, E. The CAG repeat polymorphism within the androgen receptor gene and maleness. Int. J. Androl. 26, 76–83 (2003).
Manning, J. T., Bundred, P. E., Newton, D. J. & Flanagan, B. F. The second to fourth digit ratio and variation in the androgen receptor gene. Evol. Hum. Behav. 24, 399–405 (2003).
Voracek, M. No effects of androgen receptor gene CAG and GGC repeat polymorphisms on digit ratio (2D:4D): A comprehensive meta-analysis and critical evaluation of research. Evol. Hum. Behav. 35, 430–437 (2014).
Hönekopp, J. No evidence that 2D:4D is related to the number of CAG repeats in the androgen receptor gene. Front. Endocrinol. 4, (2013).
Zhang, K. et al. Revisiting the relationships of 2D:4D with androgen receptor (AR) gene and current testosterone levels: Replication study and meta-analyses. J. Neurosci. Res. 98, 353–370 (2020).
Manning, J. T., Kilduff, L. P. & Trivers, R. Digit ratio (2D:4D) in Klinefelter’s syndrome. Andrology 1, 94–99 (2013).
Chang, S. et al. Anthropometry in Klinefelter syndrome—Multifactorial influences due to CAG length, testosterone treatment and possibly intrauterine hypogonadism. J. Clin. Endocrinol. Metab. 100, E508–E517 (2015).
Ratcliffe, S. G. et al. Prenatal testosterone levels in XXY and XYY males. Horm. Res. 42, 106–109 (1994).
Voracek, M. & Dressler, S. G. Digit ratio (2D:4D) in twins: Heritability estimates and evidence for a masculinized trait expression in women from opposite-sex pairs. Psychol. Rep. 100, 115–126 (2007).
Gobrogge, K. L., Breedlove, S. M. & Klump, K. L. Genetic and environmental influences on 2D:4D finger length ratios: A study of monozygotic and dizygotic male and female twins. Arch. Sex. Behav. 37, 112–118 (2008).
Medland, S. E. & Loehlin, J. C. Multivariate genetic analyses of the 2D:4D ratio: Examining the effects of hand and measurement technique in data from 757 twin families. Twin Res. Hum. Genet. 11, 335–341 (2008).
Paul, S. N., Kato, B. S., Cherkas, L. F., Andrew, T. & Spector, T. D. Heritability of the second to fourth digit ratio (2d:4d): A twin study. Twin Res. Hum. Genet. 9, 215–219 (2006).
Ahrenfeldt, L. J., Christensen, K., Segal, N. L. & Hur, Y.-M. Opposite-sex and same-sex twin studies of physiological, cognitive and behavioral traits. Neurosci. Biobehav. Rev. 108, 322–340 (2020).
van Anders, S. M., Vernon, P. A. & Wilbur, C. J. Finger-length ratios show evidence of prenatal hormone-transfer between opposite-sex twins. Horm. Behav. 49, 315–319 (2006).
Medland, S. E., Loehlin, J. C. & Martin, N. G. No effects of prenatal hormone transfer on digit ratio in a large sample of same- and opposite-sex dizygotic twins. Personality Individ. Differ. 44, 1225–1234 (2008).
Hiraishi, K., Sasaki, S., Shikishima, C. & Ando, J. The second to fourth digit ratio (2D:4D) in a Japanese twin sample: Heritability, prenatal hormone transfer, and association with sexual orientation. Arch. Sex. Behav. 41, 711–724 (2012).
Cohen-Bendahan, C. Biological Roots of Sex Differences: A Longitudinal Twin Study (University Medical Center Utrecht, 2005).
Ventura, T., Gomes, M. C., Pita, A., Neto, M. T. & Taylor, A. Digit ratio (2D:4D) in newborns: Influences of prenatal testosterone and maternal environment. Early Human Dev. 89, 107–112 (2013).
Richards, G., Gomes, M. & Ventura, T. Testosterone measured from amniotic fluid and maternal plasma shows no significant association with directional asymmetry in newborn digit ratio (2D:4D). J. Dev. Orig. Health Dis. 10, 362–367 (2019).
Richards, G., Browne, W. & Constantinescu, M. Digit ratio (2D:4D) and amniotic testosterone and estradiol: An attempted replication of Lutchmaya et al. (2004). J. Developmental Origins Health Disease. https://doi.org/10.1101/2020.07.10.197269 (2020).
van de Beek, C., Thijssen, J. H. H., Cohen-Kettenis, P. T., van Goozen, S. H. M. & Buitelaar, J. K. Relationships between sex hormones assessed in amniotic fluid, and maternal and umbilical cord serum: What is the best source of information to investigate the effects of fetal hormonal exposure?. Horm. Behav. 46, 663–669 (2004).
Rodeck, C. H., Gill, D., Rosenberg, D. A. & Collins, W. P. Testosterone levels in midtrimester maternal and fetal plasma and amniotic fluid. Prenat. Diagn. 5, 175–181 (1985).
Hines, M. et al. Testosterone during pregnancy and gender role behavior of preschool children: A longitudinal, population study. Child Dev. 73, 1678–1687 (2002).
Udry, J. R., Morris, N. M. & Kovenock, J. Androgen effects on women’s gendered behaviour. J. Biosoc. Sci. 27, 359–368 (1995).
Tsompanidis, A. et al. Maternal steroid levels and the autistic traits of the mother and infant. Mol. Autism 12, 51 (2021).
Barona, M., Kothari, R., Skuse, D. & Micali, N. Social communication and emotion difficulties and second to fourth digit ratio in a large community-based sample. Mol. Autism 6, 68 (2015).
Hickey, M. et al. Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls: A prospective cohort study. Psychoneuroendocrinology 35, 1235–1244 (2010).
Harris, J. A., Vernon, P. A. & Boomsma, D. I. The heritability of testosterone: A study of dutch adolescent twins and their parents. Behav. Genet. 28, 165–171 (1998).
Hollier, L. P. et al. Adult digit ratio (2D:4D) is not related to umbilical cord androgen or estrogen concentrations, their ratios or net bioactivity. Early Hum. Dev. 91, 111–117 (2015).
Whitehouse, A. J. O. et al. Prenatal testosterone exposure is related to sexually dimorphic facial morphology in adulthood. Proc. R. Soc. B Biol. Sci. 282, 20151351 (2015).
Çetin, R., Can, M. & Özcan, E. The relationship between testosterone and oestrogen level of the cord blood and length of fingers of newborns 2D:4D. Balıkesır Health Sci. J. 5, 75–82 (2016).
Mitsui, T. et al. Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children. PLoS ONE 10, 1–11 (2015).
Mitsui, T. et al. Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children. Steroids 113, 46–51 (2016).
van Leeuwen, B. et al. Do sex hormones at birth predict later-life economic preferences? Evidence from a pregnancy birth cohort study. Proc. R. Soc. B Biol. Sci. 287, 20201756 (2020).
Hollier, L. P., Keelan, J. A., Hickey, M., Maybery, M. T. & Whitehouse, A. J. O. Measurement of androgen and estrogen concentrations in cord blood: Accuracy, biological interpretation, and applications to understanding human behavioral development. Front. Endocrinol. 5, 64 (2014).
Galis, F., ten Broek, C. M. A., van Dongen, S. & Wijnaendts, L. C. D. Sexual dimorphism in the prenatal digit ratio (2D:4D). Arch. Sex. Behav. 39, 57–62 (2010).
Malas, M. A., Dogan, S., Evcil, E. H. & Desdicioglu, K. Fetal development of the hand, digits and digit ratio (2D:4D). Early Hum. Dev. 82, 469–475 (2006).
Manning, J. T. & Fink, B. Are there any “direct” human studies of digit ratio (2D:4D) and measures of prenatal sex hormones?. Early Hum. Dev. 113, 73–74 (2017).
Barrett, E. et al. Digit ratio, a proposed marker of the prenatal hormone environment, is not associated with prenatal sex steroids, anogenital distance, or gender-typed play behavior in preschool age children. J. Dev. Orig. Health Dis. 12, 923–932. https://doi.org/10.1017/S2040174420001270 (2020).
Baxter, A., Wood, E. K., Witczak, L. R., Bales, K. L. & Higley, J. D. Sexual dimorphism in titi monkeys’ digit (2D:4D) ratio is associated with maternal urinary sex hormones during pregnancy. Dev. Psychobiol. https://doi.org/10.1002/dev.21899 (2019).
Ökten, A., Kalyoncu, M. & Yariş, N. The ratio of second- and fourth-digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Early Hum. Dev. 70, 47–54 (2002).
Buck, J. J., Williams, R. M., Hughes, I. A. & Acerini, C. L. In-utero androgen exposure and 2nd to 4th digit length ratio—Comparisons between healthy controls and females with classical congenital adrenal hyperplasia. Hum. Reprod. 18, 976–979 (2003).
Nave, G. et al. No evidence for a difference in 2D:4D ratio between youth with elevated prenatal androgen exposure due to congenital adrenal hyperplasia and controls. Horm. Behav. 128, 104908 (2021).
Constantinescu, M. Are Finger Ratios a Useful Measure of Androgenic Influences on Sexual Differentiation? (University of Cambridge, 2009).
Gelman, A. & Loken, E. The garden of forking paths: Why multiple comparisons can be a problem, even when there is no “fishing expedition” or “p-hacking” and the research hypothesis was posited ahead of time. http://www.stat.columbia.edu/~gelman/research/unpublished/p_hacking.pdf (2013).
Simmons, J. P., Nelson, L. D. & Simonsohn, U. False-positive psychology: Undisclosed flexibility in data collection and analysis allows presenting anything as significant. Psychol. Sci. 22, 1359–1366 (2011).
Putz, D. A., Gaulin, S. J. C., Sporter, R. J. & McBurney, D. H. Sex hormones and finger length: What does 2D:4D indicate?. Evol. Hum. Behav. 25, 182–199 (2004).
Goldacre, B. Bad Science (Fourth Estate, 2008).
Voracek, M. & Stieger, S. Replicated nil associations of digit ratio (2D:4D) and absolute finger lengths with implicit and explicit measures of aggression. Psicothema 21, 382–389 (2009).
Osu, T. et al. Fluctuating asymmetry of finger lengths, digit ratio (2D:4D), and tattoos: A pre-registered replication and extension of Koziel et al. (2010). Early Hum. Development. 152, 105273 (2021).
Fossen, F. M., Neyse, L., Johannesson, M. & Dreber, A. 2D:4D and self-employment: A preregistered replication study in a large general population sample. Entrepreneurship Theory Pract. 46, 21–43 (2022).
Ribeiro, E., Neave, N., Morais, R. N. & Manning, J. T. Direct versus indirect measurement of digit ratio (2D:4D): A critical review of the literature and new data. Evol. Psychol. 14, 1–8 (2016).
Fink, B. & Manning, J. T. Direct versus indirect measurement of digit ratio: New data from Austria and a critical consideration of clarity of report in 2D:4D studies. Early Human Dev. 127, 28–32 (2018).
Manning, J. T., Fink, B., Neave, N. & Caswell, N. Photocopies yield lower digit ratios (2D:4D) than direct finger measurements. Arch. Sex. Behav. 34, 329–333 (2005).
Kemper, C. J. & Schwerdtfeger, A. Comparing indirect methods of digit ratio (2D:4D) measurement. Am. J. Hum. Biol. 21, 188–191 (2009).
Allaway, H. C., Bloski, T. G., Pierson, R. A. & Lujan, M. E. Digit ratios (2D:4D) determined by computer-assisted analysis are more reliable than those using physical measurements, photocopies, and printed scans. Am. J. Hum. Biol. 21, 365–370 (2009).
Caswell, N. & Manning, J. T. A comparison of finger 2D:4D by self-report direct measurement and experimenter measurement from photocopy: Methodological issues. Arch. Sex. Behav. 38, 143–148 (2009).
Steier, J. A., Myking, O. L. & Bergsjø, P. B. Correlation between fetal sex and human chorionic gonadotropin in peripheral maternal blood and amniotic fluid in second and third trimester normal pregnancies. Acta Obstet. Gynecol. Scand. 78, 367–371 (1999).
Meulenberg, P. M. M. & Hofman, J. A. Maternal testosterone and fetal sex. J. Steroid Biochem. Mol. Biol. 39, 51–54 (1991).
Klinga, K., Bek, E. & Runnebaum, B. Maternal peripheral testosterone levels during the first half of pregnancy. Am. J. Obstet. Gynecol. 131, 60–62 (1978).
Vlková, B. et al. Testosterone and estradiol in maternal plasma and their relation to fetal sex. Prenat. Diagn. 30, 806–807 (2010).
Nabi, G., Aziz, T., Amin, M. & Khan, A. A. Effect of fetal sex on total levels of maternal serum testosterone. J. Biol. Life Sci. 5, 58–64 (2014).
Firestein, M. R. et al. Elevated prenatal maternal sex hormones, but not placental aromatase, are associated with child neurodevelopment. Horm. Behav. 140, 105125 (2022).
Sarkar, P., Bergman, K., Fisk, N. M., O’Connor, T. G. & Glover, V. Amniotic fluid testosterone: Relationship with cortisol and gestational age. Clin. Endocrinol. 67, 743–747 (2007).
Aydin, E. Fetal Biometry and Early Behavioural Development (University of Cambridge, 2020).
Hogeveen, K. N. et al. Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunction. J. Clin. Investig. 109, 973–981 (2002).
DeBruine, L. AutoMetric software for measurement of 2D:4D ratios (2006).
Legro, R. S. et al. Total testosterone assays in women with polycystic ovary syndrome: Precision and correlation with hirsutism. J. Clin. Endocrinol. Metab. 95, 5305–5313 (2010).
Al Kindi, M. K., Al Essry, F. S., Al Essry, F. S. & Mula-Abed, W.-A.S. Validity of serum testosterone, free androgen index, and calculated free testosterone in women with suspected hyperandrogenism. Oman Med. J. 27, 471–474 (2012).
Ernsten, L., Körner, L. M., Heil, M., Richards, G. & Schaal, N. K. Investigating the reliability and sex differences of digit lengths, ratios, and hand measures in infants. Sci. Rep. 11, 10998 (2021).
Knickmeyer, R. C., Woolson, S., Hamer, R. M., Konneker, T. & Gilmore, J. H. 2D:4D ratios in the first 2 years of life: Stability and relation to testosterone exposure and sensitivity. Horm. Behav. 60, 256–263 (2011).
Danborno, B., Adebisi, S. S., Adelaiye, A. B. & Ojo, S. A. Relationship between digit ratio (2D:4D) and birth weight in Nigerians. Anthropologist 12, 127–130 (2010).
Kobus, M., Sitek, A., Rosset, I., Pruszkowska-Przybylska, P. & Żądzińska, E. Association of prenatal sex steroid exposure estimated by the digit ratio (2D:4D) with birth weight, BMI and muscle strength in 6- to 13-year-old Polish children. PLoS ONE 16, e0258179 (2021).
McIntyre, M. H., Cohn, B. A. & Ellison, P. T. Sex dimorphism in digital formulae of children. Am. J. Phys. Anthropol. 129, 143–150 (2006).
Ronalds, G., Phillips, D. I. W., Godfrey, K. M. & Manning, J. T. The ratio of second to fourth digit lengths: A marker of impaired fetal growth?. Early Human Dev. 68, 21–26 (2002).
Loehlin, J. C., Medland, S. E. & Martin, N. G. Relative finger lengths, sex differences, and psychological traits. Arch. Sex. Behav. 38, 298–305 (2009).
Diaconis, P. & Efron, B. Computer-intensive methods in statistics. Sci. Am. 248, 116–130 (1983).
Richards, G. et al. An examination of the influence of prenatal sex hormones on handedness: Literature review and amniotic fluid data. Horm. Behav. 129, 104929 (2021).
Wilke, M. & Schmithorst, V. J. A combined bootstrap/histogram analysis approach for computing a lateralization index from neuroimaging data. Neuroimage 33, 522–530 (2006).
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